Endocrine Abstracts

Adrenal incidentalomas are incidentally discovered adrenal tumors by imaging methods without any prior suspicions of adrenal disease. Most of these tumors are functionally inactive but thorough investigations can reveal discrete hormone excess. Chromogranin A(CgA) is expressed in neuroendocrine cells throughout the body, including large and small intestine, adrenal medulla and pancreatic islets. It is a marker for carcinoid tumors, paragangliomas, and other neuroendocrine tumo...

IntroductionAlternative splicing allows the generation of multiple RNA isoforms from a single pre-RNA molecule, and thereby contributes to a multitude of physiological processes, but can also be involved in many diseases, including cancer. Indeed, disruption of alternative splicing has been linked to key cancer features, such as tumor growth, metastasis and hormone responsiveness and is increasingly regarded as a novel and transversal cancer hallmark. Th...